2005: Environmental Epigenomics, Imprinting and Disease Susceptibility
Durham, NC: The 'early origins hypothesis' of Barker states that environmental factors, such as nutrition acting in early life, program the risks for adverse health outcomes in adult life. This hypothesis is now supported by a number of epidemiological studies performed worldwide. Environmental perturbations during gestation are also known to affect adult phenotype by altering gene expression through the modification of DNAÂ methylation and chromatin structure. The objective of this conference is to discuss the evidence that genomic elements, such as transposons and imprinted genes, can function as epigenetically labile targets for linking environmental exposures during early development to adult susceptibility of developing medical conditions such as asthma, cancer, behavioral disorders, cardiovascular disease, diabetes, and obesity.
ORGANIZERS: Randy L. Jirtle (Duke University) and Fred Tyson (NIEHS)
Invited Speaker Presentations
The following is a list of the Environmental Epigenomics conference speakers and their addresses, along with links to their presentation abstracts and recordings.
- Trevor Archer — Laboratory of Molecular Carcinogenesis, NIEHS
- Marisa Bartolomei — Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine
- Manel Esteller — Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO)
- Andrew Feinberg — Department of Medicine, Molecular Biology and Genetics, and Oncology, Johns Hopkins University School of Medicine
- David Haig — Department of Organismic and Evolutionary Biology, Harvard University
- Andrew Hoffman — Department of Medicine, Stanford University
- Jean-Pierre Issa — Department of Leukemia, M.D. Anderson Cancer Center
- Randy Jirtle — Department of Oncology, University of Wisconsin-Madison
- Joanne Kurtzberg — Department of Pediatrics - Bone Marrow Program, Duke University Medical Center
- Jeannie Lee — Howard Hughes Medical Institute, Department of Genetics , Harvard Medical School
- Haifan Lin — Department of Cell Biology, Duke University Medical Center
- Victor Lobanenkov — Section of Molecular Pathology, Laboratory of Immunopathology, National Institutes of Health
- John McLachlan — Center for Bioenvironmental Research, Tulane and Xavier Universities
- Adele Murrell — Senior Cancer Research Fellow, Hutchison/MRC Research Centre, Department of Oncology, University of Cambridge
- Marcus Pembrey — Institute of Child Health, UCL
- Jorge Piedrahita — United States
- Bruce Richardson — Department of Medicine, University of Michigan
- Douglas Ruden — Department of Environmental Health Sciences, University of Alabama at Birmingham
- Gerald Schatten — Departments of Obstetrics , University of Pittsburgh School of Medicine
- David Schwartz — University of Colorado
- David Skuse — Behavioural and Brain Sciences Unit, Institute of Child Health
- Moshe Szyf — Department of Pharmacology and Therapeutics , McGill University
- Donata Vercelli — College of Medicine , University of Arizona
- Paul Wade — Laboratory of Molecular Carcinogenesis , NIEHS
- Robert Waterland — Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Children's Nutrition Research Center
- Emma Whitelaw — School of Molecular and Microbial Biosciences, University of Sydney
Attendee Presentations
- Gregory Bean — Division of Medical Oncology, Duke University Medical Center
- Hans Bjornsson — Predoctoral Program in Human Genetics, Johns Hopkins University School of Medicine
- Francisco Cisneros — Preclinical Services, Charles River Laboratories
- James Curley — Sub-Department of Animal Behaviour, University of Cambridge
- Tomas Ekstrom — Department of Clinical Neuroscience, Karolinska Institutet
- Rosalind John — School of Biosciences, Cardiff University
- Sarah Lewis — Department of Social Medicine, University of Bristol
- Philippe Luedi — Center for Bioinformatics and Computational Biology, Duke University Medical Center
- Riyaz Mahammad — Department of Biomedical Sciences, University of Rhode Island
- Carmen Sapienza — Fels Institute for Cancer Research, Temple University Medical School
- Sue Varmuza — Department of Zoology, University of Toronto
- Paula Vertino — Winship Cancer Institute, Emory University School of Medicine
- xx-PANEL DISCUSSION-xx — Moderators , Terry Graedon and Joe Graedon - People's Pharmacy
Conference Sponsors
National Institute of Environmental Health Sciences • Duke Comprehensive Cancer Center • Duke Department of Radiation Oncology • Duke University Integrated Toxicology Program • Duke University Superfund Basic Research Center • Rete Mirabile Fund of the Triangle Community Foundation • Elsevier's Advances in Developmental Biology • Sumitomo Chemical Company • Merck Research Laboratories • OncoMethylome Sciences • Roche Applied Science • Amplicon Express • GlaxoSmithKline • AstraZeneca • Diagenode
