Geneimprint

• 2005 Durham
• 2002 Washington
• 2002 London
• 2001 Osaka
• 1999 Dublin
• 1998 Durham

1999: Genomic Imprinting Conference

Dublin, Ireland: Welcome to the website for the Genomic Imprinting Conference, held in August 1999. Over 150 scientists from throughout the world attended this 3 day conference in Dublin, IRELAND. Many people were unable to attend this conference because of space limitations. Therefore, we have placed the symposium abstracts and speaker presentations on this website. Speakers included: David Haig (USA), Maxwell Lee (USA), Randy Jirtle (USA), Robert Lyle (NETHERLANDS), Rolf Ohlsson (SWEDEN), Rudolf Jaenisch (USA), Wolf Reik (UK), Azim Surani (UK), Bernard Horsthemke (GERMANY), Marcus Pembrey (UK), Andrew Hoffman (USA), David Skuse (UK), Laurence Hurst (UK), Paul Schofield (UK).

ORGANIZER: Amanda McCann (University College of Dublin)

Invited Speaker Presentations

The following is a list of the Environmental Epigenomics conference speakers and their addresses, along with links to their presentation abstracts and recordings. Audio is in MP3 format and video requires Shockwave Flash.

• Luisa Dandolo — Inserm U257, ICGM
  24 Rue du Fbg. St. Jacques; Paris 75014; France • p: +33 144 41 24 55 / f: +33 144 41 24 62 / e: dandolo@cochin.inserm.fr
  • "Asynchronous Replication of the H16/Igf2 Imprinted Region in a Mouse Model"
    Abstract / Audio / Video
• David Haig — Department of Organismic and Evolutionary Biology, Harvard University
  Cambridge, MA 02138; United States • p: 617-496-5125 / f: 617-495-5667 / e: dhaig@oeb.harvard.edu
  • "Genomic Imprinting and the X Chromosome"
    Abstract / Audio / Video
• Andrew Hoffman — VA Medical Center
  Palo Alto, CA 94301; United States • p: 650-858-3930 / f: 650-856-8024 / e: arhoffman@leland.stanford.edu
  • "DNA Methylation, Histone Acetylation and Imprinting"
    Abstract / Audio / Video
• Bernhard Horsthemke — Institut fur Humangenetik, Universitatsklinikum Essen
  Essen; Germany • p: +49 201 723 4556 / f: +49 201 723 5900 / e: g.horsthemke@uni-essen.de
  • "Establishment of Parental Imprints on Human Chromosome 15"
    Abstract / Audio / Video
• Laurence Hurst — Department of Biology and Biochemistry, University of Bath
  Bath BA2 7AY; United Kingdom • p: +44 1225 826424 / f: +44 1225 826779 / e: l.d.hurst@bath.ac.uk
  • "The Evolution of Mutation Rates: Lessons from X-Linked and Imprinted Genes"
    Abstract / Audio / Video
• Rudolf Jaenisch — Whitehead Institute for Biomedical Research
  9 Cambridge Center; Cambridge, MA 02142; United States • p: 617-258-5186 / f: 617-258-6505 / e: jaenisch@wi.mit.edu
  • "Genomic Imprinting, Nuclear Cloning and the Reprogramming of the Genome"
    Abstract / Audio / Video
• Randy Jirtle — Department of Radiation Oncology, Duke University Medical Center
  Box 3433Duke University Medical Center; Duham, NC 27710; United States • p: 919-684-6203 / f: 919-684-5584 / e: jirtle@radonc.duke.edu
  • "Imprinting Evolution and Cancer"
    Abstract / Audio / Video
• Maxwell Lee — Johns Hopkins University School of Medicine
  720 Rutland Avenue; Baltimore, MD 21205; United States • p: 410-614-3489 / f: 410-614-9819 / e: rnpl@welch.jhu.edu
  • "Genetic and Epigenetic Changes of Imprinted Genes in BWS and Cancer"
    Abstract / Audio / Video
• Robert Lyle — The Netherlands Cancer Institute
  Plesmanlaan 121; Amsterdam 1006 CX; The Netherlands • p: +31 20 512 2020 / f: +31 20 512 2011 / e: lyle@nki.nl
  • "IGF2R: Sense and Antisense"
    Abstract / Audio / Video
• Rolf Ohlsson — Department of Animal Development and Genetics, Uppsala University
  Norbyvagen 18A; Uppsala S.752636; Sweden • p: +46 18 4712660 / f: +46 18 4712683 / e: rolf.ohlsson@devbiol.uu.ee
  • "Structural and Functional Aspects of an Imprinting Control Region Upstream of the Mouse H19 Gene"
    Abstract / Audio / Video
• Marcus Pembrey — Institute of Child Health, University College London
  30 Guilford Street; London WC1N 1EH; United Kingdom • e: mpembrey@picketts.u-net.com
  • "Genomic Imprinting and the Possible Role of Epigenetic Inheritance in Transgenerational Effects"
    Abstract / Audio / Video
• Wolf Reik — Department of Development and Genetics, The Babraham Institute
  Cambridge CB2 4AT; United Kingdom • p: +44 1223 832312 / f: +44 1223 836481 / e: wolf.reik@bbsrc.ac.uk
  • "Deletion of a Mesodernal Silencer in Igf2 Results in Biallelic Expression"
    Abstract / Audio / Video
• Paul Schofield — Laboratory of Stem Cell Biology, Department of Anatomy, University of Cambridge
  Downing Street; Cambridge CB2 3DY; United Kingdom • p: +44 1223 333893 / f: +44 1223 333786 / e: ps@mole.bio.cam.ac.uk
  • "Control of IGF2 Imprinting in Beckwith-Wiedemann Syndrome"
    Abstract / Audio / Video
• David Skuse — Behavioural Sciences Unit, Institute of Child Health
  30 Guilford Street; London WC1N LEM; United Kingdom • p: +44 171 831 0975 / f: +44 171 831 7050 / e: dskuse@ich.ucl.ac.uk
  • "The Contribution Made by X-Linked Imprinted Genes to Brain Development in Humans"
    Abstract / Audio / Video
• Azim Surani — Wellcome CRC Institute, University of Cambridge
  Tennis Court Road; Cambridge CB2 1QR; United Kingdom • p: +44 1223 3341 36 / f: +44 1223 3341 82 / e: as10021@mole.bio.cam.ac.uk
  • "Characterization and Functions of Imprinted Genes on Proximal Chromosome 7"
    Abstract / Audio / Video

Attendee Presentations

• Justin Ainscough — Wellcome/CRC Institute
  Tennis Court Road; Cambridge; United Kingdom • p: +44 1223 334138 / e: jfxa1@mole.bio.cam.ac.uk
  • "Imprinting of Igf2 and H19 from a 130KB YAC Transgene"
    Abstract / Audio / Video
• Valerie Amarger — Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences
  BMC Box 597; Uppsala 751 24; Sweden • p: +46 18 471 4903 / f: +46 18 50 44 61 / e: valerie.amargen@bmc.uu.se
  • "Towards a Molecular Characterization of an Imprinted QTL Affecting Muscle Mass in Pig"
    Abstract / Audio / Video
• David E. Barton — National Centre for Medical Genetics, Our Lady's Hospital for Sick Children
  Crumlin; Dublin 12; Ireland • p: +353 1 4550515 / f: +353 1 4560953 / e: david.barton@olhsc.ie
  • "Hyperinsulinism: A Recessive Disorder Caused By a Single Paternally Inherited Mutation"
    Abstract / Audio / Video
• David Bonthron — Human Genetics Unit, Level 1, Molecular Medicine Centre, Western General Hospital
  Edinburgh EH4 2XU; United Kingdom • p: +44 141 651 1040 / f: +44 131 651 1059 / e: bonthron@ed.ac.uk
  • "An Imprinted Antisense Transcript at the Human GNAS1 Locus"
    Abstract / Audio / Video
• Carole Charlier — Genetic, B43, Faculty of Veterinary Medicine, University of Liege
  20 bd de Colonder; Liege 4000; Belgium • p: +32 4 366 4126 / f: +32 4 366 4122 / e: carole.charlier@ulg.ac.be
  • "Positional Cloning of the Callipyge Gene: A Step Towards Understanding a Novel Form of Dominant Negative Imprinting"
    Abstract / Audio / Video
• Karen Ruth Davies — Department of Development and Genetics, The Babraham Institute
  Cambridge CB2 4AT; United Kingdom • p: +44 1223 496 356 / f: +44 1223 496 030 / e: karen.davies@bbsrc.ac.uk
  • "The Radiation-Induced Mouse Mutation, Minute (Mnt), Affects the Mesoderm Enhancer for Igf2 and Methylation of H19"
    Abstract / Audio / Video
• Robert Feil — The Babraham Institute
  Cambridge CB2 4AT; United Kingdom • p: +44 1223 496332 / f: +44 1223 496332 / e: robert.feil@bbsrc.ac.uk
  • "Specialized Chromatin Organization at Differentially Methylated Imprinting-Control Regions"
    Abstract / Audio / Video
• Anne Ferguson-Smith — Department of Anatomy, University of Cambridge
  Downing Street; Cambridge CB2 3DY; United Kingdom • p: +44 1223 333 761 / f: +44 1223 333 786 / e: afsmith@mole.bio.cam.ac.uk
  • "Parental-Origin Specific Histone H4 Acetylation in the Imprinted Igf2/H19 Domain"
    Abstract / Audio / Video
• Mathias Frevel — Lerner Research Institute, Cleveland Clinic Foundation
  9500 Euclid Avenue; Cleveland, OH 44195; United States • p: 216-445-9653 / f: 216-444-3164 / e: frevelm@ccf.org
  • "Sequence and Methylation Analysis Refines the Region of H19 Epimutation in Wilms' Tumor and Identifies a Potential Imprint Control Element"
    Abstract / Audio / Video
• Valirie Grandjean — Department of Anatomy, University of Cambridge
  Downing Street; Cambridge CB2 3DY; United Kingdom • p: +44 1223 339 543 / f: +44 1223 333 786 / e: vg2l4@mole.bio.cam.ac.uk
  • "Increased IGF2 Protein Affects p57KIP2 Expression In Vivo and In Vitro: Implications for the Beckwith-Wiedemann Syndrome"
    Abstract / Audio / Video
• Richard Gregory — Programme in Developmental Genetics, The Babraham Institute
  Babraham Hall, Babraham; Cambridge CB2 4AT; United Kingdom • p: +44 1223 496 335 / f: +44 1223 496 030 / e: richard.gregory@bbsrc.ac.uk
  • "Differential Nuclease Sensitivity in U2afl-Rs1 is Associated with Allele-Specific Histone H4 Acetylation"
    Abstract / Audio / Video
• Edith Heard — Unite de Genetique Moleculaire Murine, Institut Pasteur
  25 rue du Docteur Roux; Paris 75724; France • p: +33 1 45 68 86 53 / f: +33 1 45 68 86 56 / e: eheard@pasteur.fr
  • "Human XIST YAC Transgenes Show Partial X-Inactivation Center Function in Mouse Embryonic Stem Cells"
    Abstract / Audio / Video
• Megan Hitchins — Molecular Biology Laboratory, Department of Maternal and Fetal Medicine, Queen Charlotte's and Chelsea Hospital
  Goldhawk Road; London W6 OXG; United Kingdom • p: +44 181 383 3533 / f: +44 181 383 3922 / e: m.hitchins@rpms.ac.uk
  • "Analysis of the Imprinting Status of the Growth Factor Receptor Bound Protein 10 (GRB10): A Prime Candidate for Silver-Russell Syndrome"
    Abstract / Audio / Video
• Fumitoshi Ishino — Gene Research Center, Tokyo Institute of Technology
  4259 Nagatsutacho; Midori-ku 226-8501; Japan • p: +81 45 924 5812 / f: +81 45 924 5814 / e: fishino@bio.titech.ac.jp
  • "Regulation Mechanism of Imprinted Genes: Pegs and Megs"
    Abstract / Audio / Video
• Rosalind John — Wellcome/CRC Institute
  Tennis Court Rd; Cambridge CB2 1QR; United Kingdom • p: +44 1223-334138 / e: rmj22@cus.cam.ac.uk
  • "Analysis of Expression and Imprinting of p57Kip2 from a Modified BAC Transgene"
    Abstract / Audio / Video
• Claudine Junien — Clinique Maurice Lamy (secteur bleu) Porte 15, Hospital Necker Enfants Malades
  149-161 Rue de Sevres; Paris 75743; France • p: +33 1 44 49 44 79 / f: +33 1 47 83 32 06 / e: junien@necker.fr
  • "Loss of Imprinted Genes and Paternal SUR1 or KIR6.2 Mutations Lead to Focal Form of Congenital Hyperinsulinism"
    Abstract / Audio / Video
• Tom Moore — Department of Developmental Genetics, Barbraham Institute
  Cambridge CB2 4AT; United Kingdom • p: +44 1223 496252 / f: +44 1223 496032 / e: tom.moore@bbsrc.ac.uk
  • "Mammalian X Chromosome Imprinting: Conflict or Agreement?"
    Abstract / Audio / Video
• Mitsuo Oshimura — Department of Molecular and Cellular Genetics, Tottori University
  Nishimashi 86; Yonago, Tottori 683-8503; Japan • p: +81 859 34 8260 / f: +81 859 34 8134 / e: oshimura@grape.med.tottori-u.ac.jp
  • "No title"
    Abstract / Audio / Video
• Malfalda Pinto — Spain
  • "hMLH1 Gene Promoter Methylation is the Major Cause of Microsatellite Instability in Gastric Cancer"
    Abstract / Audio / Video
• Aharon Razin — Department of Cellular Biochemistry and Human Genetics, The Hebrew University of Jerusalem Medical School
  Jerusalem 91120; Israel • p: +972 2 675 8172 / f: +972 2 6 415848 / e: razina@md2.huji.ac.il
  • "SNRPN Minimal Promoter Sequence: Implications for Imprint Regional Control"
    Abstract / Audio / Video
• Andrea Riccio — Centro Di Endocrinologia e Oncologia, CNR, Napoli
  Via S. Pansini, 5; Napoli 80131; Italy • p: +39 81 7462056 / f: +39 81 7703285 / e: riccioan@cds.unina.it
  • "Genomic Imprinting and Carcinogenesis: Study of an Experimental Model"
    Abstract / Audio / Video
• Rachel Smith — Developmental Genetics Programme, The Babraham Institute
  Babraham Hall, Babraham; Cambridge CB2 4AT; United Kingdom • p: +44 1223 496 325 / f: +44 1223 496 030 / e: rachel.smith@bbsrc.ac.uk
  • "The Identification of Novel Imprinted Loci Using Methylation Sensitive Representation Difference Analysis (Me-RDA)"
    Abstract / Audio / Video
• Masako Tada — Mammalian Development Laboratory, National Institute of Genetics
  YATA 1111; Mishima, Shizuoka 441-8540; Japan • p: +81 559 81 6830 / f: +81 559 81 6828 / e: matada@lab.nig.ac.jp
  • "Choice of Imprinted X-Chromosome Inactivation in Oocyte Growth"
    Abstract / Audio / Video
• Jorn Walter — Max-Planck-Institute for Molecular Genetics
  Ihnestr. 73; Berlin D-14195; Germany • p: +49 30 841 31274 / f: +49 30 841 31285 / e: walter@mpimg-berlin-dahlem.mpg.de
  • "DNA Methylation and Imprinting During Early Development"
    Abstract / Audio / Video
• Chris Williamson — MRC Mammalian Genetics Unit
  Harwell, Oxfordshire; United Kingdom • p: +44 1235 834 393 / f: +44 1235 834 446 / e: c.williamson@har.mrc.ac.uk
  • "A Cluster of Imprinted Transcripts at the Gnas Locus on Distal Mouse Chromosome 2"
    Abstract / Audio / Video
• Yinhua Yu — UT M.D. Cancer Center
  1515 Holcombe Blvd.; Houston, TX 77030; United States • p: 713-792-3790 / f: 713-794-1807 / e: yyu@notes.mdacc.tmc.edu
  • "The Mechanism Leading to Silencing of ARH1, an Imprinted Putative Tumor Suppressor Gene, in Ovarian and Breast Cancers"
    Abstract / Audio / Video