Geneimprint

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• Human Imprintome DNA Methylation Array
• DNA methylation of imprint control regions associated with Alzheimer's disease
• Twentieth Anniversary of the Agouti Mouse Study
• Human Imprintome Genomic Map
• KCNK9 Loss of Imprinting in Triple Negative Breast Cancer
• Fifty Years of Research - Randy L. Jirtle
• I had an Epiphany: Desire to Voluntarily Exercise May Be Epigenetically Determined in the Womb
• William G. Kaelin, Jr. - Recipient of the 2019 Nobel Prize in Physiology or Medicine
• Jirtle Receives EMGS 2019 Alexander Hollaender Award
• Pioneer Scientists: Jack Fowler and Alfred Knudson
• Imprintome Definition Clarified
• Western Diet Blocks Gut Microbiome Programing of the Host Epigenome
• Imprinted Genes Implicated in the Puzzle of Autism
• Environmental Lead Exposure in Early Childhood Alters Imprinted Gene Regulation
• p16 Epimutation Causes Cancer
• Antagonistic Growth Promoting Effects of Imprinted Genes
• Autism and Schizophrenia: The Antithesis of Each Other?
• Environmental Epigenomics in Health and Disease
• Radiation Epigenetics
• These Little Piggies!
• Epigenetic Basis of Suicide Risk?
• Genome-wide Mapping of Human Imprinted Genes
• Negative Bisphenol A Effects on the Epigenome Blocked by Nutritional Supplements
• Imprinted and More Equal
• Genistein methylates the fetal epigenome
• Genome-wide prediction of imprinted murine genes
• Phylogenetic footprint analysis of IGF2 in extant mammals
• Assisted Reproductive Technology: Cautionary Signs
• Imprinting Evolved Over 125 Million Years Ago
• The Price of Silence
• Callipyge Mutation Identified
• Divergent Evolution in M6P/IGF2R Imprinting: Implications for Cloning and Cancer
• IGF2 Imprinting Evolution in Mammals
• Marsupials and Eutherians Reunited
• Imprinting of PEG3
• M6P/IGF2R Imprinting Evolution in Mammals

Genome-wide prediction of imprinted murine genes

1 June 2005: A machine learning approach was used to both identify imprinted gene candidates and predict their parental expression preference across the entire mouse genome. This is the first large-scale prediction of imprinted genes based on DNA sequence characteristics alone.

Of 23,788 annotated autosomal mouse genes, 600 (2.5%) were predicted with high probability to be imprinted, 64% of which are predicted to exhibit maternal expression. The number, type, and relative orientation of repeated elements flanking a gene were found to be particularly important in predicting whether a gene is imprinted.

This subset of genes is particularly important medically becasue imprinted genes could function as epigenetically labile targets for linking environmental exposures during pregnancy to the susceptibility of developing chronic disorders as adults (Waterland and Jirtle, Nutrition 20: 63-68, 2004). Consistent with imprinted genes potentially being mechanistically involved in the developmental origins of adult diseases (Barker, J Am Coll Nutr 23(6 Suppl): 588S-595S, 2004) was our ability to identify strong candidate genes for complex human conditions where parent-of-origin inheritance is involved, including Alzheimer disease, autism, bipolar disorder, diabetes, male sexual orientation, obesity, and schizophrenia.

For example, the mouse homologue of human NKX6B at 10q26 (IDDM, 605955) was predicted to be imprinted and maternally expressed, making it a good candidate for maternal transmission of male homosexuality linked to this chromosomal region (Mustanski et al., Hum. Genet. 116: 272-278, 2005). Similarly, the mouse homologue of human GAD2 at 10p12 (IDDM, 138275) was predicted to be imprinted and maternally expressed. It is therefore a good candidate for maternal transmission of increased risk for obesity linked to this chromosomal region (Dong et al., Am. J. Hum. Genet. 76: 427-437, 2005).